Irish singer Sinéad O'Connor often made headlines in the late 1980s and 1990s with her Grammy-winning songs and rebellious attitude. However, as her fame grew in her 20s, she began to suffer from depression.
O'Connor's depression steadily got worse, including suicidal thoughts, until she was finally diagnosed with bipolar disorder at the age of 37. She talked openly about living with this condition on The Oprah Winfrey Show in 2007.
"Every pore of you is crying and you don't even understand why or what," she says. "I actually kind of died and got born again as a result of taking the meds and having a chance to, you know, build a life."
Vincent van Gogh
Legendary artist Vincent van Gogh painted some of the world's best-known works, such as The Starry Night. However, he is also remembered for his difficult, eccentric, and moody personality.
There is no consensus on what medical condition fueled van Gogh's behavior, though some theories include epilepsy, depression, psychotic attacks, and bipolar disorder.
One article published in the American Journal of Psychiatry says: "Van Gogh had earlier suffered two distinct episodes of reactive depression, and there are clearly bipolar aspects to his history. Both episodes of depression were followed by sustained periods of increasingly high energy and enthusiasm, first as an evangelist and then as an artist."